Nurangiz Panahova
Azerbaijan
Title: The relationship of immune-inflammatory reactions and hemorheological indicators in patients with stable angina pectoris after invasive intervention
Biography
Biography: Nurangiz Panahova
Abstract
The aim is to study the role of immune-inflammatory processes and the importance of hemorheological changes, as well as to determine correlation relationship between inflammatory markers in patients suffering from stable ischemia disease after coronary angioplasty and stenting.
Materials and methods. 64 patients implanted with 103 stents in general have been included to the research. During 2-24 months after stent implantation angiography examination have been done by defining caugulograma (fibrinogen, PM, INR), C-reactive protein (CRP), fibrinogen, as well as necrosis factor of cysts from pro-inflammatory cytokines (-É‘), interleukins (IL), IL-6, IL-8 in blood serum of patients suffering from IHD. In angiography, 20 patients having stenosis less than 50% has been accepted as control group by evaluating stent as open. The average age of the patients has been 58,6+1,2.
Result. Average indicator of concentration of CRP, fibrinogen and cytokines in patients suffering from IHD has been exact high in comparison with the control group patients whose stents are open after coronary angioplasty and stenting. CRP has been 16,4+1,2 (intragroup variation 6-36) mg/L and 6,8+0,4 (intragroup variation 5-10) mg/L, p<0,001, fibrinogen as 3,47+0,08 and 4,22+0,11, p<0,001 respectfully in the restenosis and non-restenosis group. During correlative analysis, the expected intense correlation has been defined as r=0,707 p<0,01 between TNF-alpha and IL-6, r=0,575 p<0,01 between CRP and IL-6, r=0,610 p<0,01 between TNF-alpha and IL-8, r=0,502 p<0,01 between IL-8 and CRP, r=0,316 p<0,05 between IL-6 and fibrinogen in the restenosis group.
Conclusion. After angioplasty in the development of coronary restenosis inflammatory-oriented markers and severe phase proteins act as diagnostic and prodiagnostic marker and there is statistic exact correlation between the levels of these markers and complication degree of IHD. In some cases high level of immune-inflammatory markers has been accompanied by change of rheological characteristics of blood. Defining inflammatory response markers in stenocardias after stent implantation can be useful for determining patients biased to high complication risk after myocardial revascularization, as well as preventing aggravation of ischemic incidents in long term.